Indeed, all the event described above are representative and perfectly in line with what could happen to DCs during their development in the presence of NPC SEVs in the tumour context, and the consequence in term of regulatory gene overexpression (Supplementary data 6 B and D), metabolism shift, and both cytokine release and T cell anergy is strongly in favour of the role of Gal9/TIM3 axis so. The gene discussed is LGALS9; the disease is nasopharyngeal carcinoma.