Although oligomeric intermediates on thepathway to amyloid fibrilformation of several proteins, such Aβ, Tau, and α-synuclein,continue to gain attention as central players in the pathogenesisof neurodegenerative diseases,31,32 very little is knownabout the biochemical, biophysical, and pathogenic properties of TDP-43oligomers, which are essential for elucidating the role of TDP-43oligomers in health and disease. Here, MAPT is linked to neurodegenerative disease.