In the first study, the lead candidate (E)-5-[(8-methoxy-2-methylquinolin-4-yl)amino]-N’-(4-methylthio)benzylidene-1H-indole- carbohydrazide bound NR4A1 with a KD of 3.58 μM and was highly cytotoxic to cancer cell lines (Li et al., 2020). The gene discussed is NR4A1; the disease is cancer.