NR4A1 and cancer: Subsequent studies showed that 4-hydroxyphenyl (DIM8) and 4- carbomethoxy-phenyl (DIM14) analogs activated NR4A1-dependent transactivation in cancer cells and also bound NR4A1 in a direct binding assay that measured fluorescent quenching of a Trp in the LBD (Chintharlapalli et al., 2005; Lee et al., 2010, 2014).