For example, the PAX3-FOX01 fusion gene is oncogenic and a major driver of alveolar rhabdomyosarcoma (ARMS) tumor growth in children and in mouse models and DIM8 inhibits NR4A1-regulated PAX3-FOX01 and downstream genes in ARMS cells and in animal models (Lacey et al., 2017). This evidence concerns the gene NR4A1 and alveolar rhabdomyosarcoma.