Interestingly NR4A2 also regulates autophagy and DIM12 decreases ATG7 and ATG12 gene expression in pancreatic cancer cell and tumors (Zarei et al., 2021), whereas celastrol induced NR4A1-dependent autophagy, demonstrating opposing effects of NR4A1 and NR4A2 ligands which may also be cell context dependent. This evidence concerns the gene NR4A2 and familial pancreatic carcinoma.