NR4A2 and experimental autoimmune encephalomyelitis: Modeling/SAR studies were used to identify the NR4A2 ligand isoxazolo-pyridinone (Hintermann et al., 2007) which was active in vivo as an inhibitor of experimental autoimmune encephalomyelitis in mice (Montarolo et al., 2014) and Dubois and coworkers (2006) found that several benzimidazoles were potent NR4A2 ligands.