NR4A2 and Parkinson disease: In solid tumors DIM12 acts as an inverse agonist to inhibit pro-oncogenic NR4A2-dependent tumor growth, survival, migration, and invasion (Karki et al., 2020a) and in neuronal models of inflammation and Parkinson’s disease (PD) DIM12 inhibits inflammation (De Miranda et al., 2015; Hammond et al., 2015, 2018; Hu et al., 2017).