Similar to our study, Van Esch et al. identified a nonsense variant resulting in a stop codon in exon 4 of GATA3 (c.828C>T, p.(Arg277*), heterozygote) in patients with hypoparathyroidism and bilateral sensorineural deafness but without renal anomalies, suggesting a reduced penetrance for renal anomalies of nonsense variants (4). The gene discussed is GATA3; the disease is hypoparathyroidism.