In response to SARS-CoV-2 S-RBD (Figure 1B) and SARS-CoV-2 ICL (Figure 1C), we observed significantly increased frequencies of CD4+ T cells expressing IFN-γ, IL-2, and IL-17A in MIS-C compared to children with COVID-19 and other infectious diseases. Here, CD4 is linked to COVID-19.