TNF and Schnyder corneal dystrophy: The gene expression of TNF-α was increased in the HFD group compared to the SCD group (P < 0.05), while its expression was reduced in mice fed with either L. paracasei TD3 or B. coagulans T4 alone, as well as in the animals treated with the combination of both organisms, compared to the HFD control group (Figure 2A).