INS and obesity due to melanocortin 4 receptor deficiency: Also, HFD-fed mice showed higher levels of FBG, serum insulin, and serum TG in comparison with the SCD group (P = 0.0001), indicating that L. paracasei TD3 and B. coagulans T4, either alone or in combination with each other, could reduce the levels of these metabolic parameters in mice models of obesity (Table 2).