This study aimed to investigate the effects of Nar on ketoprofen-RGD anticancer activity via the CaM/PDE/cAMP/PKA signaling pathway, as well as biomarkers of inflammation, and to estimate the value of Nar and ketoprofen-RGD in K562 and SKOV3 to investigate novel strategies for ovarian cancer and CML treatment. This evidence concerns the gene ALDH7A1 and ovarian cancer.