SLC46A1 and neoplasm: Further, transport by PCFT is optimal at acidic pHs not commonlyassociated with most tissues,13,15 and the modest levelof PCFT transport that occurs at neutral pH is suppressed by bicarbonate.16 Notably, PCFT is expressed in solid tumors includingmalignant pleural mesothelioma,17 pancreaticadenocarcinoma,18 nonsmall cell lung cancer,19 and epithelial ovarian cancer20 and is highly active in the acidic tumor microenvironment.6,13