Mature let-7 is bound by Ago proteins and incorporated into theRNA-induced silencing complex (RISC) in which it acts by binding tothe 3′-untranslated regions of mRNAs, suppressing the translationof mRNAs of oncogenic proteins, such as HMGA2, MYC and RAS.12,13 Of note, LIN28 overexpression is considered a biomarker for cancerstem cells and is associated with poor prognosis in cancer.14,15 Further, LIN28 was reported to be involved in the glucose metabolismof cancer cells.16 Therefore, LIN28 inhibitorsare promising candidates for cancer therapy. Here, FBXW7 is linked to cancer.