Management of elevated blood pressure, renin-angiotensin-aldosterone system (RAAS) blockade, which commonly includes angiotensin-converting enzyme-1 (ACE-1) as well as angiotensin receptor blockers (ARB) for high blood pressure and albuminuria, glycemic management, and metabolic acidosis restoration are four treatments that can significantly delay the progression of CKD. This evidence concerns the gene REN and chronic kidney disease.