BMI, body mass index; ECOG, Eastern Cooperative Oncology Group; PS, performance status; HBV, hepatitis B virus; HCV, hepatitis C virus; T-Bil, total bilirubin, ALB; albumin; PT, prothrombin time; ICGR15, indocyanine green retention rate at 15 minutes; AST, asparate aminotransferase; ALT, alanine aminotransferase; PLT, platelet count; HCC, hepatocellular carcinoma; ICC, intrahepatic cholangiocarcinoma; CCC, combined hepatocellular and cholangiocarcinoma. The gene discussed is F2; the disease is intrahepatic cholangiocarcinoma.