T2DM remission was attained in 81% Roux-en-Y gastric bypass and 19% sleeve gastrectomy patients two years after surgery. Patients with Roux-en-Y gastric bypass lost more weight and had lower levels of HbA1c, glucose, insulin resistance, and smaller waist circumference than sleeve gastrectomy patients. The gene discussed is INS; the disease is type 2 diabetes mellitus.