Overall, the biopsy is an invasive method that should be reserved only for selected patients; at the beginning, the evaluation of ovarian reserve should be done through noninvasive methods such as plasmatic screening of FSH, AMH, and inhibin B. The extent and rate of decline of the plasmatic level of AMH, the reduction of inhibin B, and the increase of FSH are associated with ovarian failure. The gene discussed is AMH; the disease is ovarian dysfunction.