IL2 and Granuloma: We know that, at the TT pole, the infection is limited by a strong cell-mediated immunity, guaranteed by Th1 CD4+ cells, that secretes interleukin 2 (IL-2), and interferon (IFN)-γ that enhance macrophages and natural killers (NKs) microbicidal activities; therefore, in TT lesions, a granuloma formation and a low number of bacterial are observed (Modlin, 1994; Misra et al., 1995; Mi et al., 2020).