Two miRNAs that target PRKCE gene (hsa-miR-1-3p and hsa-miR-31-5p), which in turn is involved in TLR-4 signaling in mycobacterial infections (Hestvik et al., 2005), showed low expression in leprosy tissues of both TT and LL poles through miRNA sequencing (Salgado et al., 2018). Here, TLR4 is linked to leprosy.