PIR and leprosy: Considering that, piR-hsa-27283, was the only piRNA upregulated, it may be useful as a risk biomarker of leprosy, more specifically, for TT patients, since it was DE for this pole, and as leprosy poles have different immunological and molecular features, it is suggested that piR-hsa-27283 functions can have a significant impact on progression to TT leprosy.