MYC and obesity due to melanocortin 4 receptor deficiency: Recent research from our lab has demonstrated that transgenic mice, bearing overexpression of c-Myc only in hepatocytes (Alb-myctg) and fed a standard chow diet are predisposed to moderate obesity and aberrant hepatic lipid accumulation with ageing (Nevzorova et al., 2013; Guo et al., 2021).