The acidic pH of the tumor microenvironment inhibits immune surveillance and response, as it impairs the activity of cytotoxic cells and hinders cytokine secretion (tumor necrosis factor-alpha, interferon-gamma, IL-10, IL-12, and transforming growth factor-beta1) (Müller et al., 2000; Flentie et al., 2012). This evidence concerns the gene IFNG and neoplasm.