IL4 and neoplasm: In contrast, M2 macrophages, also known as alternatively activated, are polarized by anti-inflammatory molecules Interleukin-4 (IL-4) and Interleukin-13 (IL-13) and are characterized by supporting tumor growth angiogenesis, metastasis, and resistance to chemotherapeutics (Perrotta et al., 2018; Di Mitri et al., 2019).