TNF and hypertensive disorder: Indeed, it was recently reported that aldosterone-producing adenoma patients have higher expression of proinflammatory cytokines and fibrosis markers, such as interleukin-6, tumor necrosis factor-α, fibronectin, and transforming growth factor-β-1, in perirenal and subcutaneous adipose tissue depots than normotensive people and patients with essential hypertension [45].