Finally, in the present study, we have characterized mutations relevant to varying degrees of preleukemic perturbation and different clinical contexts; DNMT3A and TET2 mutations are the most common drivers of clonal hematopoiesis,47,48,49 while JAK2 and CALR mutations are rather specific to myeloproliferative neoplasms and secondary AML.2 This evidence concerns the gene CALR and acute myeloid leukemia.