DNMT3A and myeloproliferative disorder: Finally, in the present study, we have characterized mutations relevant to varying degrees of preleukemic perturbation and different clinical contexts; DNMT3A and TET2 mutations are the most common drivers of clonal hematopoiesis,47,48,49 while JAK2 and CALR mutations are rather specific to myeloproliferative neoplasms and secondary AML.2