CALR and myeloproliferative neoplasm: Moreover, the unfolded protein response genes, reported to be upregulated in CALR-mutated myeloproliferative neoplasms,37 were significantly upregulated in our Calr mutant model with pseudotemporal expression patterns similar to those in patients with CALR-mutated essential thrombocythemia37 (Figures S5B–S5F).