We also identified HOX family TFs (HOXA9, HOXB9, HOXC9, and HOXD9) in KMT2A-rearranged ALL, GATA family TFs (GATA2, GATA3, GATA4, GATA5, and GATA6) in ZNF384-rearranged ALL, and nuclear receptor family TFs (ESR1, ESR2, RARA, and THRB) in PAX5-altered ALL that all had strong subtype-enriched TF footprints. Here, ESR1 is linked to acute lymphoblastic leukemia.