ATAC-seq using the Fast-ATAC10 method was performed on recently harvested primary ALL cells from 156 patients spanning ten B-ALL molecular subtypes (BCR::ABL1, DUX4-rearranged, ETV6::RUNX1, high hyperdiploid, low hypodiploid, KMT2A-rearranged, Ph-like, PAX5-altered, TCF3::PBX1, and ZNF384-rearranged) and B-other samples (Table S1) from diverse medical centers, research groups, and clinical trials networks across the United States (see STAR Methods). This evidence concerns the gene ETV6 and acute lymphoblastic leukemia.