To better understand chromatin accessibility within B-ALL, inter-subtype analyses were performed to identify DASs exhibiting subtype-enriched signal (henceforth referred to as subtype-enriched DASs) in ten B-ALL molecular subtypes harboring known molecular drivers (BCR::ABL1, DUX4-rearranged, ETV6::RUNX1, high hyperdiploid, low hypodiploid, KMT2A-rearranged, Ph-like, PAX5-altered, TCF3::PBX1, and ZNF384-rearranged; Figures 4A–4C). Here, DUX4 is linked to precursor B-cell acute lymphoblastic leukemia.