Strikingly, our results further uncovered that 46% of DASs with higher chromatin accessibility in B-ALL (i.e., B-ALL-enriched DASs) also exhibit AP-1 TF occupancy (Figure 3F), thereby supporting the activation of AP-1 TF-associated cis-regulatory in B-ALL. This evidence concerns the gene FOS and precursor B-cell acute lymphoblastic leukemia.