We also identified known B-ALL molecular drivers (e.g., DUX4 and ZNF384 in DUX4-rearranged and ZNF384-rearranged ALL, respectively) and previously documented gene-regulatory alterations in B-ALL (e.g., HOXA9 and MEIS1 activity in KMT2A-rearranged ALL). This evidence concerns the gene DUX4 and precursor B-cell acute lymphoblastic leukemia.