Therefore, to better inform gene connectivity, we produced chromatin looping data using promoter capture Hi-C21 across ten patient samples (BCR-ABL1, ETV6-RUNX1, KMT2A-rearranged, Ph-like, TCF3-PBX1, and B-other subtypes) and seven B-ALL cell lines (697, BALL1, Nalm6, REH, RS4;11, SEM, and SUP-B15) to complement B-ALL patient chromatin-accessibility profiles. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.