Nearly one-third (28.8%; 2,615/9,080 ATAC-QTLs) of these ATAC-QTLs overlapped a TF-bound motif footprint across multiple B-ALL subtypes, suggesting that most ATAC-QTLs do not have a clear TF-binding mechanism regarding how they impact chromatin accessibility. This evidence concerns the gene TF and precursor B-cell acute lymphoblastic leukemia.