Additionally, Tanshinone IIA sulfonate has been found to reduce the production of IL-1β, IL-6, MMP-1, and MMP-3 in TNF-α-induced RA FLS and inhibit their proliferation, migration, invasion, and inflammation by regulating the MAPK/NF-κB pathway (Wang Z. et al., 2019). This evidence concerns the gene IL1B and rheumatoid arthritis.