PRKD1 and infection: Rezaee et al. demonstrated the early and late phase phosphorylation of PKD leading to cortactin phosphorylation destabilizing the actin cytoskeleton and disruption of AJCs like occludins, Zonula Occludens (ZO) −1 and tight junctions, confirmed by confocal microscopy and loss of TEES (transepithelial electrical resistance) in epithelial cell culture post infection with live RSV, and not with ultraviolet (UV) inactivated RSV (38).