IFNA1 and viral infectious disease: Although pretreatment with IFN-α was correlated with decrease in levels of inflammatory markers (35), Lee et al. found conflicting evidence as similar levels of antiviral IFN-β and IFN stimulated genes (ISGs) were found in subjects with CRSwNP and control group, post viral infection in cultured sinonasal epithelial cells, thus refuting their role in immune dysregulation seen in CRS patients (30).