TEAD4 and cancer: Moreover, increased ECM stiffness can induce exosome secretion by tumor cells that was shown to promote cancer growth via paracrine Notch signaling, remodeling of the tumor microenvironment (74) as well as the activation of Yes-associated protein (YAP) and the YAP/TEA domain transcription factor 4 (TEAD4) complex in cancer cells (75, 76).