Tumor cells can recruit platelets into hepatic tumor tissue through the release of tumor cell-derived chemokine (CX3C motif) ligand 1 (CX3CL1) (259) and cancer cells can express molecules such as podoplanin and thrombin, which interact with platelet C-type lectin-like receptor 2 (CLEC-2) and protease-activated receptors (PARs) to activate and aggregate platelets (260–263). This evidence concerns the gene PDPN and neoplasm.