PDGFB and Hepatic fibrosis: observed that mitogenic PDGF-B, in liver fibrosis, was exclusively produced by activated platelets, and a monoclonal blocking antibody against PDGF-B as well as anti-platelet therapy with low-dose aspirin reduced circulating PDGF-B levels and significantly ameliorated liver fibrosis in two mouse models of advanced biliary fibrosis (120).