Additionally, accumulating evidence demonstrates FAK signaling is overexpressed and activated in many tumor cells where it is critically involved with many diverse cell types (immune, stromal and tumor) and cellular/humoral processes (cytokines, chemokines, growth factors, ECM) within the tumor microenvironment that promote cell survival, proliferation, and metastasis resulting in poor prognosis (39, 40). Here, PTK2 is linked to neoplasm.