In vitro and in vivo experiments showed that LRRK2 phosphorylates Endophilin A1 at serine 75 (S75) and at threonine 73 (T73), which regulates membrane remodeling and endocytosis activity of Endophilin A1, disrupts SVE and neurotransmission, and ultimately leads to PD development (46, 77). This evidence concerns the gene LRRK2 and Parkinson disease.