To uncover further the role of monocyte subsets in EBA disease and the specific function of CCR2 and CX3CR1 in the spatiotemporal dynamics of monocytes, we used CCR2RFP/+ (CCR2-reporter) and CX3CR1GFP/+ (CX3CR1-reporter) mice to monitor the recruitment of monocyte populations into the inflamed skin tissue. Here, CX3CR1 is linked to acquired epidermolysis bullosa.