However, in the middle and late stages of cancer development, the release of some cytokines (such as IL-4 and IL-10) leads to the polarization of TAMs to the M2 phenotype so that the TME enters an immunosuppressive state, thereby promoting tumor cell proliferation and distant migration and inhibiting the killing effect of T cells on tumor cells, affecting its antitumor effect (33). The gene discussed is IL10; the disease is neoplasm.