Next, in SW-480 cells, PAQR3 overexpression was found to inhibit cell proliferation rate, anchorage-independent growth, epidermal growth factor-stimulated ERK phosphorylation, and epidermal growth factor-induced nuclear accumulation of β-connexin, and enhanced these colorectal cancers by PAQR3 knockdown. The gene discussed is EGF; the disease is colorectal cancer.