experimentally found that MDSCs in liver metastases from colorectal cancer patients express TNFR2 and that in TNFR2-/- mice, the reduction of intrahepatic MDSCs coincided with the reduction of Treg accumulation at the metastatic site, further concluding that TNF receptor-2 promotes an immunosuppressive microenvironment in the liver that facilitates the colonization and growth of liver metastases. The gene discussed is TNFRSF1B; the disease is colorectal cancer.