Activation of the androgen receptor increases the expression of bone morphogenetic protein (BMP) inhibitors but decreases the expression of BMP4 and Wnt inhibitors in primary stromal cells, which promotes the growth of intestinal organoids.Overall, this study reveals the role of androgens in promoting proliferation and inhibiting differentiation, suggesting that stromal cells constitute the microenvironment of intestinal stem cells, it provides a possible explanation for the high incidence of colorectal cancer in men (18). This evidence concerns the gene AR and colorectal cancer.