Eleven studies excluded type 1 allergies,4,8,11–15,17,20,21,23 three excluded patients with symptoms consistent with severe type 1 allergies such as history of collapse, angioedema and anaphylaxis,19,22,24 and two studies only excluded severe IgE-mediated reactions if they occurred less than 10 years ago.16,18. This evidence concerns the gene IGHE and allergic disease.