In this context, TRIM3 expression is regulated by p53, an interplay that has been further explored in colorectal cancer (Han et al., 2023), but it is unknown whether this is relevant to its role in brain cancers, despite the p53 pathway being dysregulated in over 80% of glioblastoma (GBM) patients (Zhang et al., 2018). The gene discussed is TP53; the disease is colorectal cancer.