In adults, however, TRIM47 is more strongly localized to brain blood vessel endothelial cells, which may impact tumor growth by delivering oxygen and nutrients to the expanding tumor mass, thus correlating with increased TRIM47 expression in higher grade gliomas, although this has not yet been explored (Hanahan and Weinberg, 2011; Hao et al., 2019; Ji et al., 2021; Mishra et al., 2022). The gene discussed is TRIM47; the disease is central nervous system cancer.