TRIM8 re-localizes from the cytoplasm of healthy neurons to the nucleus in GBM cells to establish a stem-like phenotype, with an increase in malignancy and glioblastoma stem cell markers, such as STAT3, SOX2, Nestin, and Nanog (Zhang C. et al., 2017; Venuto et al., 2019). The gene discussed is SOX2; the disease is glioblastoma.