TRIM11 and cancer: TRIM11 is found in neurons of the cerebellum and basal ganglia in healthy adults and is also is expressed during development to regulate stem-like factors, as described in the section above on cancer, with TRIM11 knockdown resulting in the accumulation of cytotoxic insoluble aggregates of PAX6 (Tuoc and Stoykova, 2008; Jabbari et al., 2018).