In a murine neuroblastoma model TRIM32 enhances differentiation by catalyzing the addition of stabilizing ubiquitin chains (linkage type not defined) to the retinoic acid receptor (RARα), a factor that has well-known roles in neuronal differentiation (Sato et al., 2011; Janesick et al., 2015). The gene discussed is TRIM32; the disease is neuroblastoma.