TRIM17-mediated neuronal apoptosis in that context is part of an orchestrated programme required for proper cerebellar developmental morphogenesis and is responsive to neurotrophic factor signaling through the PI3K/Akt/GSK signaling axis, which is, interestingly, also upregulated in glioma (Lassot et al., 2010; Yamaguchi and Miura, 2015). The gene discussed is TRIM17; the disease is central nervous system cancer.