MAPT and Alzheimer disease: The dysregulation of tau is also an important mechanism in Alzheimer’s (AD) and Huntington’s (HD) diseases, where it can form cytotoxic aggregates in its hyperphosphorylated form, suggesting that TRIM18-mediated degradation of tau phosphatase PP2A may contribute to neurodegeneration, although this requires further study (Schweiger et al., 2017; Rawat et al., 2022).