Corticotropin‐releasing hormone (CRH) is expressed in the paraventricular nucleus of the hypothalamus.[53] Its expression was inhibited in the dietary obesity mice, agreeing with the transition of the Crh locus from chromatin state S1 in Chow‐3 M mice to state S6 in HFD‐3 M mice (Figure 6f). This evidence concerns the gene CRH and obesity due to melanocortin 4 receptor deficiency.