Notably, CD68 and SPP1, which were markers for pro‐angiogenic TAMs with immunosuppressive properties,26 were highly expressed in the bin cluster of ‘Macrophage/Fibroblasts’ in two tumours (P39 and P52) (Figure 3D,H), suggesting that POSTN+ CAFs and SPP1+ macrophages might be close in spatial positioning in the TME of NSCLC. Here, SPP1 is linked to neoplasm.