Second, the upregulated TCF12 protein might enter the nucleus via its nuclear localisation signal and interact with IGH::DUX4, likely through R76/R79/R80‐D393/E394 hydrogen bonding and shared DNA binding/recognition between DRE and TRE motifs, to complete a positively self‐regulatory loop in the IGH::DUX4–TCF12 transcription complex, triggering the development of full‐fledged leukaemia, which held the potential to function as a pivotal drug therapeutic target for the management of this particular form of leukaemia (Figure 7K). This evidence concerns the gene DUX4 and leukemia.