It modulates the secretion of GnRH as well as luteinizing hormone, subsequently influencing the manifestation of PCOS.[57] Ghrelin, another gut-derived peptide, has the potential to regulate the hypothalamic-pituitary axis and the secretion of luteinizing hormone, thereby ameliorating the reproductive dysfunction commonly observed in PCOS patients. Here, GHRL is linked to polycystic ovary syndrome.