The diagnosis of POEMS syndrome was confirmed by further examinations, including (but not limited to) immunology, electromyography, VEGF measurement, IFE, PET-CT, and bone marrow biopsy, which revealed polyneuropathy, monoclonal M protein expression, sclerosing bone disease, lymphadenopathy, skin changes, multiple serous cavity effusions, and an increased blood VEGF level. This evidence concerns the gene VEGFA and Abnormality of the skin.