VHL and metastatic malignant neoplasm in the lymph nodes: Only in combined analysis, patients with ≥ 2 variant alleles of all 4 polymorphisms in VHL and HIF1A genes (VHL rs779805, HIF1A rs11549465, HIF1A rs11549467, HIF1A rs2057482) in their study were significantly associated with localized clinical stage and less frequency of lymph node metastasis.