VHL and nonpapillary renal cell carcinoma: In literature 2 SNPs, rs779805 and rs1642742 involving both A and G, located in the promoter and 3′-UTRs of the VHL gene are suspected to be informative and implicated in the occurrence of ccRCC worldwide.[9,20–23] Because previous studies have found contradictory proofs on the relationship between VHL polymorphisms and ccRCC susceptibility, in the present study, we investigated the associations of VHL rs779805 and rs1642742 polymorphisms with risk, clinicopathological characteristics, and survival of ccRCC cases.