VHL and renal cell carcinoma: It should be noted that most studies investigated the associations of VHL rs779805 and rs1642742 polymorphisms with risk, clinicopathological characteristics, and survival of ccRCC cases were conducted on Asian populations.[9,20,24] To our knowledge, so far only one study has been conducted on the European (exactly Dutch) population.[12] Therefore, more extensive research is required to address the clinical adequacy of these 2 genetic polymorphisms and RCC in European population.