HIF1A and renal cell carcinoma: It has been reported that the most useful role for VHL mutational status may be in combination with other potential biomarkers, such as, for example, HIF1A or VEGF polymorphisms.[4,26–29] In line with our results, Qin et al[9] observed no significant associations between the genotypes of rs779805 in VHL and survival of RCC patients.