Similarly, In a literature review study that intended to identify the Biomarkers associated with COVID-19 disease progress, Ponti et al[23] found that a multiplicity of biomarkers are associated with the disease including: (1) hematological (lymphocyte count); (2) neutrophil count; (3) NLR; (4) inflammatory (CRP); (5) ESR; (6) PCT; (7) immunological (interleukin [IL]-6) and biochemical (D-dimer, troponin, creatine kinase); and (8) aspartate aminotransferase, especially those related to coagulation cascades in disseminated intravascular coagulation and acute respiratory distress syndrome. This evidence concerns the gene CRP and Disseminated intravascular coagulation.