Lan et al suggested that serum SCGF may interact with the stem cell factor pathway on keratinocytes to promote disease progression.[45] Keratinocytes recruit mast cells by secreting stem cell factor, and as a result, mast cells releases inflammatory mediators, including histamine, VEGF, IL-6, and IL-8, which increase endothelial permeability and vasodilation and recruit inflammatory cells to promote inflammatory responses.[46] Currently, we know little about SCGF-β and its role in acne pathogenesis. This evidence concerns the gene IL6 and acne.