IL10 and Hyperkeratosis: In normal human skin, this cytokine is not expressed in keratinocytes, but it can be induced after UV-B irradiation[29], IL-10 exerts immunosuppressive and anti-inflammatory effects by inhibiting c-interferon production.[30,31] Acne can affect IL-10 cytokine expression, which has been associated with a good prognosis in acne patients, [32,33] IL-10 can inhibit the production of c-interferon by producing inflammatory mediators to reduce the inflammatory response, [34] inhibit apoptosis, and prevent hyperkeratosis.[35] Therefore, IL-10 may reduce the risk of acne through various mechanisms.