MIP-1α/CCL3 is a member of the chemokine family involved in various biological processes, such as inflammatory responses and immune regulation.[37] Clinical observational studies or meta-analyses linking MIP-1α with acne are limited, but our MR analysis found that high levels of circulating MIP-1α were associated with a reduced risk of acne (OR = 0.55, 95% CI = 0.388–0.787, P = .001 per 1 SD increase). Here, CCL3 is linked to acne.