IGHE and allergic disease: Patients who develop a carboplatin-associated allergy reportedly have higher levels of basophil expression of the IgE receptor-1 fragment (FcεRI) and express higher levels of FcεRI mRNA in peripheral blood, which is an IgE-dependent mechanism of FcεRI overexpression is involved in carboplatin-induced severe HSRs[11] and may be present in patients with nedaplatin-associated HSRs.