The expression of CTLA-4 plays a crucial role in sustaining chronic inflammation observed in endometriosis, thereby influencing the development of infertility.[46] Although DES and MBNL1 have not been extensively studied in the context of endometriosis, our investigation examined their correlation with pivotal endometriosis-related and immune microenvironment regulatory genes. This evidence concerns the gene CTLA4 and Infertility.