MAPK3 and endometriosis: Involvement of the HOXA10 transcription factor in the development of endometriosis is important.[47] Through activation of the Akt and MAPK/Erk1/2 signaling pathways, the chemokine CCL2 exerts an autocrine effect to enhance the survival and invasiveness of endometrial stromal cells.[48] The primary function of TP53 is to regulate the cell cycle progression and apoptosis.