In an LLC-OVA (Lewis lung carcinoma) tumor model, although tumors were unresponsive to anti-PD-L1 treatment in either wild-type or PI3KδD910A mice, tumors were reduced by anti-CTLA-4 treatment in wild-type but not PI3KδD910A mice (29). This evidence concerns the gene CTLA4 and Carcinoma, Lewis Lung.