Mesenchymal stem cells (MSCs)-derived exosomes contain tumor-inhibiting miRNAs (miR-3940-5p/miR-22-3p/miR-16-5p), which inhibits the proliferation, migration and invasion of CRC cells by regulating Ras-associated protein B2 (RAP2B)/phosphoinositide 3-kinase (PI3K)/AKT signaling pathway and integrin alpha 2/6 (ITGA2/6), thereby showing therapeutic potential in the UC and CRC [168]. The gene discussed is RAP2B; the disease is colorectal carcinoma.