In addition, GDC-0084 monotherapy only reduced the phosphorylation levels of AKT, mTOR, p70S6, and 4E-BP1 in the AKT/mTOR signaling pathway but had no effect on the MEK/ERK signaling pathway in GBM cells (Fig. 3C, D). This evidence concerns the gene EIF4EBP1 and glioblastoma.