In addition, GDC-0084 monotherapy only reduced the phosphorylation levels of AKT, mTOR, p70S6, and 4E-BP1 in the AKT/mTOR signaling pathway but had no effect on the MEK/ERK signaling pathway in GBM cells (Fig. 3C, D). The gene discussed is AKT1; the disease is glioblastoma.