AKT1 and glioblastoma: Interestingly, the combination of GDC-0084 and AZD-9291 simultaneously inhibited the MEK/ERK and the AKT/mTOR signaling pathways (Fig. 3C, D), indicating that this combination inhibited GBM cell proliferation by simultaneously blocking the activation of the MEK/ERK and AKT/mTOR signaling pathways.