AKT1 and glioblastoma: In this study, GDC-0084 alone had significant inhibitory effect against various GBM cell lines and primary GBM cells, by blocking the cell cycle progression, inhibiting the phosphorylation of AKT, mTOR, p70S6, and 4E-BP1, and subsequently blocking the PI3K/AKT/mTOR signaling pathway to inhibit GBM growth.