After adjusting all covariates, we found higher levels of waist-to-hip ratio, SBP, DBP, and CRP, lower levels of HDL, and having a history of metabolic disease or hypertension medication were associated with an increased risk of breast cancer, respectively (waist-to-hip ratio: HR = 1.13, 95%CI 1.07,1.19; SBP: HR = 1.08, 95%CI 1.02,1.15; DBP: HR = 1.09, 95%CI 1.02,1.17; CRP: HR = 1.13, 95%CI 1.06,1.20; HDL: HR = 1.13, 95%CI 1.06,1.21; and A history of metabolic disease or hypertension medication: HR:1.07, 95%CI 1.01,1.14). The gene discussed is CRP; the disease is Other metabolic disease.