This study utilized bibliometric analysis of publications indexed in the Web of Science Core Collection (WoSCC) database to achieve the following objectives: (i) illustrate the research trend of PSMA in PCa over the past decade; (ii) make an overall knowledge structure of this domain; (iii) identify and elucidate the challenging issues and research hotspots concerning PSMA in PCa; and (iv) offer valuable insights to guide future research endeavors in this area. This evidence concerns the gene FOLH1 and posterior cortical atrophy.