On the other hand, insulin resistance leads to skeletal muscle reduction by inhibiting protein synthesis in skeletal muscle through the mammalian target of rapamycin complex 1 (mTORC1) or ribosomal protein S6 kinase beta-1 (S6 K1) pathway and exacerbating proteolytic gluconeogenesis [41–43]. Here, RPS6KB1 is linked to Insulin resistance.