WFDC2 and neoplasm: The four indicators of CA125, HE4, maximum diameter of tumor, and ascites in the early stage malignant group were greater than those in the benign group, and the difference was statistically significant (P < 0.05); there were no statistically significant differences in age, menopausal status, CA199 level, regardless of consideration of a multinodular cyst, peritoneal thickening, a clear tumor boundary, or the degree of enhancement, between the two groups (P > 0.05).