In addition, another OGTT and hyperinsulinemic euglycemic glucose clamp study showed that postprandial insulin clearance (the rate of removal of insulin from plasma) is a function of the amount of insulin delivered to organs that clear insulin, so people with obesity and insulin resistance have low postprandial insulin clearance because of high insulin secretion rate (ISR) and postprandial plasma insulin concentrations, whereas people with obesity and T2DM have “normal” insulin clearance because of defective ISR and lower postprandial insulin concentrations [22]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.