UBE2S and neoplasm: Moreover, immunohistochemical staining of the removed tumor tissues showed differential expression of autophagy-related proteins in the sh-UBE2S group (increased expression of Becline-1, LC3-B, ATG3; decreased expression of P62), suggesting that the above results indicated that the growth of transplanted tumors in the nude mouse with UBE2S knockdown was affected by the inhibition of autophagy.