In the present study, we mainly analyzed that LTE protected LPS-provoked ALI mice and cell models, and investigated the possible mechanisms of LTE by gateway analyse of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), confirming that LTE might inhibit LPS-induced injury through active ingredient Lut by regulating NF-κB signaling. The gene discussed is NFKB1; the disease is acute respiratory distress syndrome.