PCSK9 and coronary artery disorder: As shown in Supplementary Tables 2, 3, 4, 5 and 6, the total incidence of MACEs in the highest PCSK9 quartile group was significantly higher than that in the other three groups, including the non-CHD group (2.90% vs. 8.11% vs. 9.52% vs. 16.98%, p < 0.001), the CHD group (9.36% vs. 13.54% vs. 14.88% vs. 21.25%, p < 0.001), all the participants (6.68% vs. 10.22% vs. 12.47% vs. 20.64%, p < 0.001), male participants (6.76% vs. 11.58% vs. 12.91% vs. 20.68%, p < 0.001), and female participants (6.58% vs. 8.58% vs. 11.76% vs. 20.59%, p < 0.001).