In our study, in a group of Chinese Han T2DM patients, the plasma level of PCSK9 was positively correlated with the severity of coronary heart disease, as shown by the linear correlation results (diseased vessels: r = 0.35, p < 0.001; GS: r = 0.46, p < 0.001, significantly). The gene discussed is PCSK9; the disease is type 2 diabetes mellitus.