Furthermore, the upward trend remained even after adjusting for age, sex, BMI, hypertension, smoking, alcohol consumption, family history of CHD, Family history of DM, FPG, HbA1c, ApoB, ApoA1, TC, TG, HDL-C, LDL-C, Lp(a), hs-CRP, HCY and sdLDL-C levels compared with those in the first quartile of PCSK9 (CHD group vs. non–CHD group: OR = 2.829, 95% CI: 1.771–4.520, p < 0.001; three vessel disease group vs. one vessel disease group: OR = 4.800, 95% CI: 2.387–9.652, p < 0.001; high GS group vs. low GS group: OR = 5.534, 95% CI: 2.733–11.208, p < 0.001) (Fig. 3, B, D, F). This evidence concerns the gene APOA1 and diabetes mellitus.