According to the univariate Cox regression analysis, there was a 6.070-fold higher risk of MACEs in the highest PCSK9 quartile group than that in the lowest (reference group) in the non-CHD group (HR: 6.070, 95% CI: 2.727–13.512, p < 0.001) (Fig. 5A). This evidence concerns the gene PCSK9 and coronary artery disorder.